DNA has been identified to be the mobile aim for lots of cytotoxic anticancer brokers for a number of many years. the information of its constitution in atomic element and the convenience with which DNA fragments (both artificial oligonucleotides and traditional sequences) should be ready and manipulated has aided the layout of compounds that bind to it with better sel- tivity. at the foundation of this knowledge, new generations of series interpreting compounds (including triplex forming oligonucleotides and minor groove binding ligands) were ready, that have the possibility of concentrating on specifc DNA sequences as anti-gene brokers. in the final 10 years, it has additionally turn into obvious that the popular DNA duplex isn't the in basic terms constitution that may be precise through DNA-binding ligands and there was elevated curiosity in triplex and quadruplex buildings as drug goals, in addition to protein- DNA complexes, reminiscent of people with nucleosomes or topoisomerases. every one of those advances has required the provision and improvement of an arsenal of options for probing the interactions in either qualitative and quantitative phrases. This v- ume of equipment in Molecular Biology brings jointly numerous suggestions which are presently important for studying those interactions. a few of these are updates on ones that have been incorporated within the previous quantity (Methods in Molecular Biology 90), released 12 years in the past, whereas others are new.

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