By Gael Cristofari

This distinctive publication explores the position of retrotransposons in human health and affliction. the facility of retrotransposons to impact the constitution of human genes is famous because the overdue 80’s. although, the advances of deep-sequencing applied sciences have shed new mild at the quantity of retrotransposon-mediated genome diversifications. those progresses have additionally ended in the invention that retrotransposon task isn't really constrained to the germline - leading to inheritable genetic adaptations - yet may also mobilize in somatic tissues, akin to embryonic stem cells, neuronal progenitor cells, or in lots of cancers. This e-book covers subject matters with regards to the consequences of retrotransposon insertions, and their effects on germline and somatic genome dynamics, but additionally speak about the position and effect of retrotransposons sequences in a broader context, together with a couple of novel issues that emerged lately (long non-coding RNA, neuronal issues, exaptation) with unforeseen connections among retrotransposons, stem mobilephone upkeep, placentation, circadian cycles or aging.

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