By Bruce C. Baguley (auth.), Jun Zhou (eds.)

With the devastating difficulty of melanoma cells turning into at the same time immune to many structurally and mechanistically unrelated medicines, the efficacy of chemotherapeutic administration of melanoma frequently turns into critically restricted. In Multi-Drug Resistance in Cancer, major researchers within the box supply complete and up to date studies of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters resembling P-glycoprotein, multidrug resistance-associated proteins, and breast melanoma resistance protein, to the drug ratio-dependent antagonism and the paradigm of melanoma stem cells. The wide quantity additionally contains recommendations to beat multidrug resistance, from the advance of compounds that inhibit drug transporter functionality to the modulation of transporter expression, in addition to recommendations for detection and imaging of drug transporters, equipment for research of drug resistance in animal versions, and methods to guage the efficacy of resistance reversal brokers. As a quantity within the hugely winning Methods in Molecular Biology™ sequence, this paintings offers the type of unique description and implementation recommendation that's the most important for purchasing optimum results.

Authoritative and state of the art, Multi-Drug Resistance in Cancer deals a state-of-art number of stories and techniques for either easy and clinician investigators who're drawn to the very important learn of melanoma multi-drug resistance mechanisms and reversal strategies.

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