By Micaela Reddy, R. S. Yang, Melvin E. Andersen

A definitive, unmarried resource of data on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is changing into more and more vital in human future health threat checks and in helping pharmacodynamic modeling for poisonous responses. prepared by means of periods of compounds and modeling reasons so clients can fast entry details, this is often the 1st complete reference of its kind.
This booklet offers an outline of the underlying rules of PBPK version improvement. Then it offers a compendium of PBPK modeling info, together with historic improvement, particular modeling demanding situations, and present practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and fragrant Compounds
* Reactive Vapors within the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and comparable Compounds
* insecticides and protracted natural Pollutants
* Dioxin and comparable Compounds
* Metals and Inorganic Compounds
* Drugs
* Antineoplastic Agents
* Perinatal Transfer
* Mixtures
* Dermal publicity Models
as well as pinpointing particular details, readers can discover assorted modeling ideas and purposes. An authoritative reference for toxicologists, ecotoxicologists, hazard assessors, regulators, pharmacologists, pharmacists, and graduate scholars in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles info from leaders within the box and discusses destiny instructions for PBPK modeling.

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