By Micaela Reddy, R. S. Yang, Melvin E. Andersen
A definitive, unmarried resource of data on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is changing into more and more vital in human future health threat checks and in helping pharmacodynamic modeling for poisonous responses. prepared by means of periods of compounds and modeling reasons so clients can fast entry details, this is often the 1st complete reference of its kind.
This booklet offers an outline of the underlying rules of PBPK version improvement. Then it offers a compendium of PBPK modeling info, together with historic improvement, particular modeling demanding situations, and present practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and fragrant Compounds
* Reactive Vapors within the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and comparable Compounds
* insecticides and protracted natural Pollutants
* Dioxin and comparable Compounds
* Metals and Inorganic Compounds
* Antineoplastic Agents
* Perinatal Transfer
* Dermal publicity Models
as well as pinpointing particular details, readers can discover assorted modeling ideas and purposes. An authoritative reference for toxicologists, ecotoxicologists, hazard assessors, regulators, pharmacologists, pharmacists, and graduate scholars in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles info from leaders within the box and discusses destiny instructions for PBPK modeling.
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In March 2001, the nationwide Institutes of healthiness issued the next caution: "The variety of websites supplying health-related assets grows on a daily basis. Many websites supply invaluable details, whereas others can have details that's unreliable or deceptive. " moreover, due to the speedy elevate in Internet-based info, many hours will be wasted looking out, deciding on, and printing.
In March 2001, the nationwide Institutes of healthiness issued the subsequent caution: "The variety of websites delivering health-related assets grows each day. Many websites offer important info, whereas others can have info that's unreliable or deceptive. " additionally, due to the fast elevate in Internet-based info, many hours could be wasted looking, making a choice on, and printing.
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