By Lennart Philipson (auth.), Professor Dr. Walter Doerfler (eds.)

A difficult epidemiological challenge was once the driver in the back of the invention of human adenoviruses via Wallace Rowe and his colleagues 30 years in the past. The de­ velopment of a plaque assay for poliomyelitis virus in 1953 led us to the edge of quantitative virology, and within the similar yr the double-helical constitution of DNA used to be found and have become a cornerstone of mo­ lecular biology. the potential for adenoviruses as learn instruments within the molecular and mobile biology of eukaryotic cells was once famous as early because the overdue Nineteen Fifties and early Sixties through a number of investigators. Structural and biochemical stu­ dies ruled the early years. In 1962, a number of the adenoviruses have been the 1st human viruses proven to be oncogenic in experimental animals. therefore adenovirology provided the investigator the complete gamut of host telephone interactions, effective and abortive, in addition to trans­ shaped and tumor phone structures. the probabilities that adenoviruses afforded for the learn of the molecular biology and genetics of eukaryotic cells have been totally rea­ lized within the past due Nineteen Sixties and the 1970s.

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